rs112343361 - HTR7

Magnitude 2.2 · 1 study on file

Reported associations

• Deep learning of left atrial structure and function provides link to atrial fibrillation risk - Unknown journal (n.d.) · Unknown authors · PubMed 38773065

  ABSTRACT: Increased left atrial volume and decreased left atrial function have long been associated with atrial fibrillation. The availability of large-scale cardiac magnetic resonance imaging data paired with genetic data provides a unique opportunity to assess the genetic contributions to left atrial structure and function, and understand their relationship with risk for atrial fibrillation. Here, we use deep learning and surface reconstruction models to measure left atrial minimum volume, maximum volume, stroke volume, and emptying fraction in 40,558 UK Biobank participants. In a genome-wide association study of 35,049 participants without pre-existing cardiovascular disease, we identify 20 common genetic loci associated with left atrial structure and function. We find that polygenic co

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