rs11232439 - COX6A1P4 - MTND4LP18
Magnitude 4.5 · 1 study on file
Reported associations
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Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia - Unknown journal (n.d.) · Unknown authors · PubMed 33632238
ABSTRACT: Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic risk of CVDs specific to individuals with metabolic diseases. This study aimed to identify disease-specific and/or common genetic loci associated with CVD susceptibility in chronic metabolic disease patients. Methods We conducted a genome-wide association study (GWAS) of a multiple case-control design with data from the City Cohort within Health EXAminees subcohort of the Korean Genome and Epidemiology Study (KoGES_HEXA). KoGES_HEXA is a population-based prospective cohort of 173,357 urban Korean adults that had health examinations at medical centers. 42,393 pa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for ischemic stroke Moderate
This rs11232439 variant confers increased ischemic stroke risk in hypertensive individuals; medical review ensures appropriate prevention and management strategies
Share this genetic information with your physician; discuss stroke prevention strategies tailored to your risk profile
Screening
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Blood pressure monitoring Moderate
This variant associates with increased ischemic stroke risk in hypertensive contexts; regular BP monitoring enables early hypertension detection and management
Annual blood pressure screening at minimum; quarterly if any hypertension diagnosis