rs11231991 - TENM4 - RNU6-544P
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. - Neurobiology of aging (2014) · Zhang C, Pierce BL · PubMed 24468470
Age-related cognitive decline is a major public health concern facing a large segment of the US population. To identify genetic risk factors related to cognitive decline, we used nationally representative longitudinal data from the US Health and Retirement Study to conduct genome-wide association studies with 5765 participants of European ancestry, and 890 participants of African ancestry. Mixed effects models were used to derive cognitive decline phenotypes from data on repeated cognitive assessments and to perform single nucleotide polymorphism-based heritability estimation. We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with c
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cognitive health assessment and prevention strategy Moderate
SNP association with age-related cognitive decline warrants discussion of early detection and prevention approaches
Lifestyle
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Cognitive engagement and mental stimulation Moderate
Regular cognitive exercise may help maintain cognitive reserve and slow age-related decline
Daily cognitive activities such as reading, puzzles, learning new skills, or games
Screening
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Cognitive function assessment at age 50 onwards Moderate
Genetic association with age-related cognitive decline suggests benefit of early and regular monitoring
Annual or biennial cognitive screening starting at age 50