rs11231824 - SLC22A11 - SLC22A12

Magnitude 4.5 · 1 study on file

Reported associations

• GWAS in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture - Unknown journal (n.d.) · Unknown authors · PubMed 26606652

  ABSTRACT: OBJECTIVES Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. Our aim was to perform the first genome-wide association study on individuals from the Americas enriched for Native American heritage. MATERIALS and METHODS We analyzed 3,710 individuals from four countries of Latin America and the Unites States diagnosed with SLE and healthy controls. Samples were genotyped with the HumanOmni1 BeadChip. Data of out-of-study controls was obtained for the HumanOmni2.5. Statistical analyses were performed using SNPTEST and SNPGWA. Data was adjusted for genomic control and FDR. Imputation was done using IMPUTE2, and HiBAG for classical HLA alleles. RESULTS The IRF5-TNPO3 region showed the strongest association and largest odds ratio (OR) (r

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