Expressive

rs11231420 - ANKRD33BP6 - TRIM51

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative - Unknown journal (n.d.) · Unknown authors · PubMed 26545240

    ABSTRACT: Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women's Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1-3) or moderate/severe POP (grades 2-3), while controls had grade 0 POP. We performed race-specific multiple logistic regression analyses between SNPs imputed to 1000 genomes in relation to POP (grade 0 vs 1-3; grade 0 vs 2-3) adjusting for age at diagnosis, body mass index, parity, and genetic ancestry. There were 1274 controls and 1427 cases of any POP and 317 cases of moderate/severe POP. Although none of the analyses reached genome-wide significance (p<5x1

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • pelvic floor physical therapy Moderate

    Pelvic floor strengthening is evidence-based for prevention and management of pelvic organ prolapse

    Consult pelvic floor physical therapist; typical protocol is 2-3 sessions weekly for 8-12 weeks

Lifestyle

  • chronic straining and heavy lifting Moderate

    Increased intra-abdominal pressure from straining exacerbates pelvic floor dysfunction and prolapse progression

    Manage constipation with fiber/hydration; avoid heavy lifting (>25 lbs regularly); use proper lifting technique

Screening

  • pelvic floor assessment for prolapse risk Moderate

    ANKRD33BP6 variants associate with 1.64-fold increased pelvic organ prolapse risk in a genome-wide significant study of 1570 women

    Discuss baseline pelvic floor evaluation with physician to assess for prolapse symptoms or early signs