rs11231017 - SCGB2A2 - SCGB1D4

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations - Unknown journal (n.d.) · Unknown authors · PubMed 26039976

  ABSTRACT: Genome-wide association studies (GWASs) have revealed several genetic loci associated with HIV-1 outcome following infection (e.g., HLA-C at 6p21.33) in multi-ethnic populations with genetic heterogeneity and racial/ethnic differences among Caucasians, African-Americans, and Hispanics. To systematically investigate the inherited predisposition to modulate HIV-1 infection in Chinese populations, we performed GWASs in three ethnically diverse HIV-infected patients groups (i.e., HAN, YUN, and XIN, N = 538). The reported loci at 6p21.33 was validated in HAN (e.g., rs9264942, P = 0.0018). An independent association signal (rs2442719, P = 7.85 × 10−7, HAN group) in the same region was observed. Imputation results suggest that haplotype HLA-B13:02/C06:02, which can

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