rs11230729 - LRRC10B - SYT7
Magnitude 2.2 · 1 study on file
Reported associations
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Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults - Unknown journal (n.d.) · Unknown authors · PubMed 39048560
ABSTRACT: Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic blood pressure predisposition Moderate
Genetic variant contributes to blood pressure variation; integrated with clinical risk factors may guide CVD prevention strategy
discuss at next routine visit; consider formal cardiovascular risk assessment if not recently done
Screening
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blood pressure monitoring Moderate
C allele associates with elevated systolic and mean arterial pressure; tissue eQTLs show arterial expression changes
annual blood pressure measurement, or biennial if previously normal