rs1123028 - LRCH1
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS on retinal vasculometry phenotypes - Unknown journal (n.d.) · Unknown authors · PubMed 36757925
ABSTRACT: The eye is the window through which light is transmitted and visual sensory signalling originates. It is also a window through which elements of the cardiovascular and nervous systems can be directly inspected, using ophthalmoscopy or retinal imaging. Measurements of ocular parameters may therefore offer important information on the physiology and homeostasis of these two important systems. Here we report the results of a genetic characterisation of retinal vasculature. Four genome-wide association studies performed on different aspects of retinal vasculometry phenotypes, such as arteriolar and venular tortuosity and width, found significant similarities between retinal vascular characteristics and cardiometabolic health. Our analyses identified 119 different regions of associati
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular assessment Moderate
rs1123028 is associated with retinal arteriolar tortuosity, a marker of systemic vascular health status
Discuss baseline cardiovascular assessment with your physician
Screening
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baseline retinal arteriolar imaging Moderate
rs1123028 in LRCH1 is strongly associated with increased retinal arteriolar tortuosity, a marker of vascular dysfunction
Schedule baseline retinal examination or imaging; repeat as recommended by eye care provider