rs112297132 - SIK3
Magnitude 2.2 · 1 study on file
Reported associations
-
A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907
ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
Metabolic health-optimized diet pattern Moderate
Dietary composition affects insulin resistance and metabolic syndrome features; important for genetic risk mitigation.
Prioritize whole grains, vegetables, lean proteins, healthy fats; minimize processed and high-glycemic foods
Exercise
-
Regular aerobic exercise Moderate
Exercise improves insulin sensitivity and metabolic function, mitigating genetic metabolic syndrome risk.
150 minutes per week of moderate-intensity aerobic activity or equivalent
Screening
-
Metabolic syndrome components Moderate
Genetic variant increases metabolic syndrome risk; regular component screening enables early intervention.
Annual fasting measurements: glucose, triglycerides, HDL; blood pressure; waist circumference