rs112294022 - BICD1-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Unknown journal (n.d.) · Unknown authors · PubMed 41688638

  ABSTRACT: Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1-OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness. We further identified 15 study-wide significant genetic associations (P < 5.4 × 10−11) involving eight loci and 14 common bacterial species, of which 11 associations at six loci were replicated. The results confirm previously reported associations at LCT, ABO and FUT2, and provide evid

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