rs11229003 - P2RX3
Magnitude 2.2 · 1 study on file
Reported associations
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Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses - Unknown journal (n.d.) · Unknown authors · PubMed 40307439
ABSTRACT: Background Emerging evidence suggests metabolic dysregulation may contribute to colorectal cancer (CRC) aetiology. We aimed to identify pre-diagnostic metabolic biomarkers for CRC risk in 230,420 UK Biobank participants. Methods Nuclear magnetic resonance spectroscopy was used to quantify 249 metabolic biomarkers in plasma samples collected at baseline. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CIs) for associations of metabolic biomarkers with CRC risk after adjusting for potential confounders. To infer the potential causality of biomarkers that were associated with CRC independent of the others, we performed genome-wide association analyses among 199,732 UK Biobank participants of European ancestry to identify biomarker-as
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Reduce refined carbohydrates Moderate
Refined carbohydrates elevate triglycerides; rs11229003 carriers predisposed to elevated IDL triglyceride percentage
Substitute whole grains for refined grains; limit added sugars to <10% daily calories
Exercise
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Aerobic exercise Moderate
Aerobic exercise reduces triglycerides; rs11229003 carriers predisposed to elevated IDL triglyceride percentage
150 minutes moderate-intensity aerobic exercise per week
Screening
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Lipid panel with fasting triglycerides Moderate
rs11229003 associated with increased triglyceride percentage in intermediate-density lipoprotein at genome-wide significance
Annual lipid panel; more frequent if triglycerides elevated