Expressive

rs11228953 - TRIM48 - TRIM51HP

Magnitude 2.2 · 2 studies on file

Reported associations

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

  • Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608

    ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • sodium restriction for blood pressure Moderate

    Dietary sodium modulates blood pressure; reducing intake helps offset this variant's BP-raising effect

    Target less than 2300 mg sodium daily, or 1500 mg if hypertensive

Discuss with your doctor

  • hypertension prevention strategy Moderate

    Genetic predisposition to elevated blood pressure identified by GWAS warrants clinical risk assessment and preventive planning

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity lowers blood pressure; beneficial for individuals with this variant's genetic BP elevation

    Aim for 150 minutes of moderate-intensity aerobic activity weekly

Screening

  • annual blood pressure check High

    Carriers of T allele at rs11228953 show higher systolic and diastolic blood pressure in large GWAS studies

    Check blood pressure at least annually; discuss more frequent screening if family history of hypertension