rs11228719 - OR2AH1P - TMEM230P2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts - Unknown journal (n.d.) · Unknown authors · PubMed 22419666

  ABSTRACT: We performed a genome wide association analysis of maternally-mediated genetic effects and parent-of-origin effects on risk of orofacial clefting using over 2,000 case-parent triads collected through an international cleft consortium. We used log-linear regression models to test individual SNPs. For SNPs with a p-value <10−5 for maternal genotypic effects, we also applied a haplotype-based method, TRIMM, to extract potential information from clusters of correlated SNPs. None of the SNPs were significant at the genome wide level. Our results suggest neither maternal genome nor parent of origin effects play major roles in the etiology of orofacial clefting in our sample. This finding is consistent with previous genetic studies and recent population-based cohort studies in Norway

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