rs1122396 - TMEM9
Magnitude 2.8 · 1 study on file
Reported associations
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Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks - Unknown journal (n.d.) · Unknown authors · PubMed 29273806
ABSTRACT: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms. FULL TEXT: [INTRO] Asthma is a complex disease affecting hundreds of milli
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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asthma risk assessment and prevention plan Moderate
genetic variant predisposes to asthma; early identification and trigger management can reduce symptom burden
discuss screening frequency, trigger identification, and asthma action plan
Lifestyle
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minimize indoor air pollutants and allergen exposure Moderate
genetic predisposition suggests heightened respiratory sensitivity; environmental triggers may precipitate asthma
HEPA filtration in bedroom, regular cleaning, control humidity 40-60%, avoid secondhand smoke
Screening
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respiratory health and asthma symptoms Moderate
rs1122396 G allele associates with 1.32x increased asthma odds; TMEM9 eQTL in lung suggests immune/epithelial dysfunction
annual spirometry if available; report cough, shortness of breath, or chest tightness promptly