rs11223270 - OPCML
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 31969693
ABSTRACT: Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) wa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to depression Moderate
rs11223270 A allele associated with major depressive disorder in 92,957-person GWAS
review results with healthcare provider; discuss screening and prevention strategies
Screening
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depressive symptoms Moderate
Genetic risk indicates value of regular mental health assessment
implement periodic depression screening (e.g., PHQ-9 annually or biannually)