rs11222416 - SNX19 - RN7SL167P

Magnitude 4.5 · 1 study on file

Reported associations

• Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis. - GeroScience (2022) · Kulminski AM, Loiko E, Loika Y, Culminskaya I · PubMed 34743297

  Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic associations with these phenotypes may shed light on EDU-related protection against AD. We performed pleiotropic meta-analyses using Fisher's method and omnibus test applied to summary statistics for single nucleotide polymorphisms (SNPs) associated with AD and EDU in large-scale univariate GWAS at suggestive-effect (5 × 10 < p < 0.1) and genome-wide (p ≤ 5 × 10 ) significance levels. We report 53 SNPs that attained p ≤ 5 × 10 at least in one of the pleiotropic meta-analyses and were reported in the univariate GWAS at 5 × 10 <

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