rs112201895 - LINC03122 - RN7SKP157

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 31969693

  ABSTRACT: Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) wa

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