rs112176860 - VRK2
Magnitude 2.2 · 2 studies on file
Reported associations
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The Genetic Architecture of Depression in Individuals of East Asian Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 34586374
ABSTRACT: Key Points Question Are the genetic risk factors for depression the same in individuals of East Asian and European descent? Findings In this genome-wide association meta-analysis of depression in 194 548 individuals with East Asian ancestry, 2 novel genetic associations were identified, one of which is specific to individuals of East Asian descent living in East Asian countries. There was limited evidence for transferability with only 11% of depression loci previously identified in individuals of European descent reaching nominal significance levels in the individuals of East Asian descent. Meaning Caution is advised against generalizing findings about genetic risk factors for depression beyond the studied population. This genetic association study investigates the genetics of
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Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders - Unknown journal (n.d.) · Unknown authors · PubMed 33479212
ABSTRACT: Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major depressive disorder (MDD) share common clinical presentations, suggesting etiologic overlap. A substantial proportion of SNP-based heritability for neuropsychiatric disorders is attributable to genetic components, and genome-wide association studies (GWASs) focusing on individual diseases have identified multiple genetic loci shared between these diseases. Here, we aimed at identifying novel genetic loci associated with individual neuropsychiatric diseases and genetic loci shared by neuropsychiatric diseases. We performed multi-trait joint analyses and meta-analysis across five neuropsychiatric disorders based
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic depression risk and screening strategy High
rs112176860 A allele carriers show increased major depressive disorder risk in replicated GWAS studies
Discuss family depression history, personal risk factors, and appropriate screening frequency during physician visit
Screening
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Depression symptom monitoring and assessment High
Genetic susceptibility to major depressive disorder identified via GWAS; regular monitoring enables early detection
Periodic depression screening using validated tools (PHQ-9 or similar); frequency to be determined with physician