rs11216843 - MPZL2 - CD3E

Magnitude 2.2 · 1 study on file

Reported associations

• Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants - Unknown journal (n.d.) · Unknown authors · PubMed 27015805

  ABSTRACT: Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have been identified. We undertook a Genome Wide Association Study (GWAS) using age at death of parents of middle-aged UK Biobank participants of European decent (n=75,244 with father's and/or mother's data, excluding early deaths). Genetic risk scores for 19 phenotypes (n=777 proven variants) were also tested. In GWAS, a nicotine receptor locus (CHRNA3, previously associated with increased smoking and lung cancer) was associated with fathers' survival. Less common variants requiring further confirmation were also identified. Offspring of longer lived parents had more protective alleles for coronary artery disease, systolic blood pressure, body mass index, cholesterol and triglyceride levels, typ

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