Expressive

rs11216220 - SIK3

Magnitude 2.2 · 1 study on file

Reported associations

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH dietary pattern Moderate

    rs11216220 T allele associates with metabolic syndrome; these diets reduce metabolic syndrome risk

    Emphasize whole grains, legumes, fish, olive oil, vegetables; limit refined carbohydrates and processed foods

Exercise

  • Regular aerobic and resistance training Moderate

    rs11216220 T allele associates with metabolic syndrome; physical activity reduces metabolic syndrome risk

    150 minutes moderate aerobic activity weekly, plus resistance training 2-3 times weekly

Lifestyle

  • Maintain healthy BMI and waist circumference Moderate

    rs11216220 T allele associates with metabolic syndrome, which includes abdominal obesity as a diagnostic criterion

    Target BMI 18.5-24.9 kg/m2, waist circumference <40 inches (male) or <35 inches (female)

Screening

  • Annual metabolic syndrome screening Moderate

    rs11216220 T allele associates with metabolic syndrome (p=7e-10, n=107k); early detection enables intervention

    Annual blood pressure, fasting glucose, lipid panel, waist circumference