Expressive

rs11216135 - ZPR1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci - Unknown journal (n.d.) · Unknown authors · PubMed 34503513

    ABSTRACT: Background Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is often unclear. Moreover, little is known about the role of lipids on cardiovascular disease in Pakistan, a population historically underrepresented in cardiovascular studies. Methods We characterised the genetic architecture of the human blood lipidome in 5662 hospital controls from the Pakistan Risk of Myocardial Infarction Study (PROMIS) and 13,814 healthy British blood donors from the INTERVAL study. We applied a candidate causal gene prioritisation tool to link the genetic variants associated with each lipid to the most likely

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and added sugars Moderate

    Refined carbs worsen glucose and lipid profiles; this SNP affects metabolic pathways controlling these processes

    Limit refined grains and added sugars; emphasize whole grains, legumes, and whole fruits

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and lipid profiles affected by this SNP variant

    150 minutes per week moderate aerobic exercise plus 2 sessions weekly resistance training

Screening

  • metabolic syndrome screening panel Moderate

    This SNP is strongly associated with metabolic syndrome risk through effects on lipid and glucose metabolism genes (APOA1, BUD13, PCSK7)

    Annual fasting lipid panel, fasting glucose, blood pressure, waist circumference measurement