rs11216131 - BUD13

Magnitude 2.0 · 1 study on file

Reported associations

• No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity - Unknown journal (n.d.) · Unknown authors · PubMed 26379185

  ABSTRACT: While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections

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