Expressive

rs11214609 - DRD2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy. - Nature human behaviour (2023) · Hindley G, Shadrin AA, van der Meer D, Parker N, Cheng W, O'Connell KS, Bahrami S, Lin A, Karadag N, Holen B, Bjella T, Deary IJ, Davies G, Hill WD, Bressler J, Seshadri S, Fan CC, Ueland T, Djurovic S, Smeland OB, Frei O, Dale AM, Andreassen OA · PubMed 37365406

    Personality and cognitive function are heritable mental traits whose genetic foundations may be distributed across interconnected brain functions. Previous studies have typically treated these complex mental traits as distinct constructs. We applied the 'pleiotropy-informed' multivariate omnibus statistical test to genome-wide association studies of 35 measures of neuroticism and cognitive function from the UK Biobank (n = 336,993). We identified 431 significantly associated genetic loci with evidence of abundant shared genetic associations, across personality and cognitive function domains. Functional characterization implicated genes with significant tissue-specific expression in all tested brain tissues and brain-specific gene sets. We conditioned independent genome-wide association

  • Functional validity, role, and implications of heavy alcohol consumption genetic loci - Unknown journal (n.d.) · Unknown authors · PubMed 31998841

    ABSTRACT: We identify six genetic loci associated with heavy alcohol intake in humans, and provide functional validation in C. elegans. High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K. Biobank (n = 125,249) and GERA (n = 47,967) datasets to determine genetic factors associated with extreme population-level alcohol consumption and examine the functional validity of outcomes using model organisms and in silico techniques. We identified six loci attaining genome-wide significant association with alcohol consumption after meta-analysis and meeting our criteria for replication: ADH1B (lead SNP: rs1229984), KLB (rs13130794), BTF3P13 (rs144198753), GCKR (rs1260326), SLC39A8 (rs13107325)

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • DRD2 dopamine receptor variant and addiction risk High

    DRD2 variants alter dopamine signaling in reward and addiction circuits, conferring increased risk of alcohol dependence and relapse

    Discuss genetic findings; consider screening for alcohol use disorder symptoms

Lifestyle

  • alcohol consumption tracking High

    The G allele increases dopamine D2 receptor sensitivity in reward circuits, raising vulnerability to heavy alcohol consumption and dependence

    Track weekly alcohol intake; maintain within guidelines (max 14 units/week for women, 21 units/week for men)