rs112128680 - DHODH
Magnitude 2.2 · 1 study on file
Reported associations
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A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation - Unknown journal (n.d.) · Unknown authors · PubMed 35654975
ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P < 5 × 10−8). External replication in histology-defined NAFLD cohorts (7,397 cases and 56,785 controls) or radiologic imaging cohorts (n = 44,289) replicated 17 single-nucleotide polymorph
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Alanine aminotransferase (ALT) level Moderate
rs112128680 risk allele associated with chronic ALT elevation; periodic monitoring establishes baseline and detects changes
Check annually or per physician recommendation
Discuss with your doctor
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Genetic risk for liver ALT elevation Moderate
DHODH rs112128680 variant increases ALT levels in large cohorts; personalized monitoring plan optimizes early detection of changes
At routine appointment