rs112115136 - CIROZ

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability - Unknown journal (n.d.) · Unknown authors · PubMed 30531825

  ABSTRACT: Natural hair colour within European populations is a complex genetic trait. Previous work has established that MC1R variants are the principal genetic cause of red hair colour, but with variable penetrance. Here, we have extensively mapped the genes responsible for hair colour in the white, British ancestry, participants in UK Biobank. MC1R only explains 73% of the SNP heritability for red hair in UK Biobank, and in fact most individuals with two MC1R variants have blonde or light brown hair. We identify other genes contributing to red hair, the combined effect of which accounts for ~90% of the SNP heritability. Blonde hair is associated with over 200 genetic variants and we find a continuum from black through dark and light brown to blonde and account for 73% of the SNP heritabi

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