rs11210918 - ST3GAL3
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes - Unknown journal (n.d.) · Unknown authors · PubMed 33972514
ABSTRACT: Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Genetic risk score analysis using the identified SNPs is strongly associated with serum activity of liver enzymes in two independent European descent studies (The Airwave Health Monitoring study and the Northern Finland Birth Cohort 1966). Gene-set enrichment analysis using the identified SNPs highlights involvement in liver developm
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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alkaline phosphatase level Moderate
rs11210918 T allele is associated with increased alkaline phosphatase levels in large GWAS (n=437,438), warranting baseline and periodic monitoring
Include alkaline phosphatase in routine liver function panel every 1-2 years
Discuss with your doctor
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ST3GAL3 rs11210918 variant and liver enzyme implications Moderate
Elevated alkaline phosphatase can indicate liver, bone, or biliary disorders; association warrants clinical evaluation and determination of monitoring intensity