Expressive

rs11210622 - FOXJ3 - RIMKLA

Magnitude 4.5 · 1 study on file

Reported associations

  • A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39046104

    ABSTRACT: Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome‐wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of all‐cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonanc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • vascular dementia risk and prevention strategy Moderate

    rs11210622 G allele carriers show significantly elevated vascular dementia risk per large cohort GWAS; physician assessment of individual risk profile and prevention priorities warranted.

Exercise

  • aerobic exercise for cerebrovascular health Moderate

    Aerobic exercise improves endothelial function and cerebral blood flow regulation; protects against vascular dementia mechanisms linked to rs11210622.

    150 minutes moderate aerobic exercise per week

Screening

  • blood pressure and cardiovascular risk factors Moderate

    rs11210622 G allele associates with increased vascular dementia risk; hypertension and vascular disease are primary risk factors for vascular cognitive impairment.

    Check blood pressure quarterly; annual lipid panel and glucose screening