rs11210359 - RNA5SP50 - RNU4ATAC8P

Magnitude 2.0 · 1 study on file

Reported associations

• Case-case genome wide association analysis reveals markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes - Psychiatric genetics (2011) · Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM · PubMed 21057379

  ABSTRACT: Objectives There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The samples may be better matched, especially for background risk factor common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present. Method We used samples of UK bipolar and schizophrenic cases which had previously been subject to genome wide association studies and compared marker allele frequencies between the two samples. When these differed for a marker, we compared the case sample allele frequencies with those of a control sample. Results Eight markers were significant at p<10−5. Of these, the most interesting finding was for rs

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