Expressive

rs11208950 - SGIP1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 37770476

    ABSTRACT: Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (rg = 0.16 ± 0.04; p = 0.0002), as

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • whether short sleep duration impacts your health Moderate

    Individual sleep needs vary genetically; genetic predisposition may represent natural variation rather than pathological insufficiency.

Lifestyle

  • enhanced sleep quality strategies Moderate

    Genetic predisposition to shorter sleep may require optimized sleep quality to maintain health and daytime function.

    Maintain consistent sleep schedule, ensure dark/cool bedroom (under 0.3 lux, 60-67 F), avoid screens 30 min before bed

Screening

  • sleep duration and daily alertness Moderate

    This SNP associates with naturally shorter sleep duration; tracking patterns reveals whether genetic predisposition impacts individual health.

    Log sleep hours and next-day alertness for 2 weeks; identify your personal optimal duration