rs112089026 - STAG3L4 - MTATP6P21

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Contributions to Health Literacy. - Twin research and human genetics : the official journal of the International Society for Twin Studies (2020) · Fawns-Ritchie C, Davies G, Hagenaars SP, Deary IJ · PubMed 31250787

  Higher health literacy is associated with higher cognitive function and better health. Despite its wide use in medical research, no study has investigated the genetic contributions to health literacy. Using 5783 English Longitudinal Study of Ageing (ELSA) participants (mean age = 65.49, SD = 9.55) who had genotyping data and had completed a health literacy test at wave 2 (2004-2005), we carried out a genome-wide association study (GWAS) of health literacy. We estimated the proportion of variance in health literacy explained by all common single nucleotide polymorphisms (SNPs). Polygenic profile scores were calculated using summary statistics from GWAS of 21 cognitive and health measures. Logistic regression was used to test whether polygenic scores for cognitive and health-related traits w

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