rs112088479 - NOTCH2
Magnitude 2.2 · 1 study on file
Reported associations
-
The genetic basis of dermatophytosis skin infection susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 41792138
ABSTRACT: Dermatophytosis is a fungal infection affecting keratinized tissues such as skin, nails, and hair, presenting as red and itchy patches, nail thickening, or hair loss. It affects around 20% of the global population but the genetic architecture remains poorly understood. We performed a genome-wide association meta-analysis of over 250,000 cases and 1.37 million controls from FinnGen, Estonian Biobank, UK Biobank, and the Million Veteran Program and identified 30 genome-wide significant loci, including seven missense variants and two loci in high linkage disequilibrium with missense variants. Top associations were near ZNF646, HLA-DQB1, FLG, FTO, SLURP2, and KRT77. Additionally, dermatophytosis subtype analyses revealed 44 signals. Our results highlight the role of disrupted keratin
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
preventive nail and foot hygiene practices Moderate
Maintaining dry, clean nails reduces fungal growth in genetically predisposed individuals.
Keep nails short and dry; avoid prolonged moisture; use antifungal powder if prone to foot sweating.
Screening
-
nail appearance for fungal infection signs High
NOTCH2 variants affecting skin homeostasis increase dermatophytosis susceptibility, particularly nail infections.
Inspect nails regularly for discoloration, thickening, or brittleness; seek medical evaluation at first signs.