rs112081903 - PDXDC2P-NPIPB14P, NPIPB14P
Magnitude 2.2 · 1 study on file
Reported associations
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Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Unknown journal (n.d.) · Unknown authors · PubMed 40374629
ABSTRACT: Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Biobank (UKBB), it is now possible to study aging over time at genome-wide scale. In this work, we evaluated the suitability of competing models of change in realistic simulation settings, performed genome-wide association scans on simulation-validated measures of age-related deweekcline, and followed up with LD-score regression and Mendelian Randomization (MR) analyses. Focusing on global cognitive and physical function, we observed marked differences between baseline function (θ) and accelerated decline (Δ). Both outcomes showed distinct heritability levels (e.g., 31.38% versus 3.15%
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular aerobic exercise Moderate
T-allele carriers have genetic predisposition to reduced physical function and lower lung capacity; aerobic exercise mitigates both functional decline and respiratory limitation
150-300 min moderate-intensity aerobic activity per week
Screening
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baseline pulmonary function testing Moderate
rs112081903 T-allele carriers have significantly reduced forced expiratory volume; baseline spirometry establishes respiratory functional status
spirometry testing; repeat annually if results abnormal