Expressive

rs11207707 - NFIA

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture - Unknown journal (n.d.) · Unknown authors · PubMed 30048462

    ABSTRACT: Low bone mineral density (BMD) leads to osteoporosis, and is a risk factor for bone fractures, including stress fractures. Using data from UK Biobank, a genome-wide association study identified 1,362 independent SNPs that clustered into 899 loci of which 613 are new. These data were used to train a genetic algorithm using 22,886 SNPs as predictors and showing a correlation with heel bone mineral density of 0.415. Combining this genetic algorithm with height, weight, age and sex resulted in a correlation with heel bone mineral density of 0.496. Individuals with low scores (2.2% of total) showed a change in BMD of -1.16 T-score units, an increase in risk for osteoporosis of 17.4 fold and an increase in risk for fracture of 1.87 fold. Genetic predictors could assist in the identific

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate dietary calcium for bone health Moderate

    Calcium is essential for bone mineralization; genetic predisposition to lower BMD may warrant dietary optimization.

    Ensure intake of 1000-1200 mg calcium daily from food sources.

Discuss with your doctor

  • Discuss genetic predisposition to lower bone mineral density Moderate

    NFIA rs11207707 is associated with reduced heel bone mineral density, which may affect fracture risk and bone health management.

Exercise

  • Weight-bearing exercise for bone strength Moderate

    Mechanical loading from weight-bearing exercise stimulates bone formation and may offset genetic predisposition to lower BMD.

    Aim for 30 minutes moderate-intensity weight-bearing activity, 3-4 times weekly.

Screening

  • Bone mineral density screening via DXA scan Moderate

    NFIA rs11207707 is associated with reduced heel bone mineral density, indicating potential increased osteoporosis risk.

    Consider baseline DXA scan of hip and spine; repeat every 2 years if not already screened.

Supplements

  • Vitamin D supplementation if deficient Moderate

    Vitamin D is critical for calcium absorption and bone health; genetic predisposition to lower BMD may require optimization.

    Check serum 25-OH vitamin D; target 30-50 ng/mL with supplementation if below range.