rs11206965 - DAB1
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 38839884
ABSTRACT: Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X. Sex-specific meta-analyses revealed largely overlapping genetic predispositions of the sexes (rg = 0.96). Locus annotation prioritized druggable genes such as glutamate receptors 1 and 4, and Mendelian randomization indicated RLS as a causal risk factor for diabetes. Machine learning approaches combining genetic and nongen
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic predisposition to restless legs syndrome Moderate
GWAS finding indicates increased genetic risk for RLS; warrants clinical assessment and risk discussion.
Discuss this genetic finding and personal or family RLS history with healthcare provider.
Screening
-
restless legs syndrome symptoms Moderate
Genetic variant strongly associated with increased restless legs syndrome risk in large GWAS cohort.
Assess for nocturnal leg restlessness, urge to move, or sleep disruption; report findings to healthcare provider.