rs112068658 - KCNN1
Magnitude 4.5 · 1 study on file
Reported associations
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Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction - Unknown journal (n.d.) · Unknown authors · PubMed 36171425
ABSTRACT: Despite an estimated heritability of ~50%, genome-wide association studies of opioid use disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross-ancestry meta-analysis of OUD in the Million Veteran Program (N = 425,944). In addition to known exonic variants in OPRM1 and FURIN, we identified intronic variants in RABEPK, FBXW4, NCAM1 and KCNN1. A meta-analysis including other datasets identified a locus in TSNARE1. In total, we identified 14 loci for OUD, 12 of which are novel. Significant genetic correlations were identified for 127 traits, including psychiatric disorders and other substance use-related traits. The only significantly enriched cell-type group was CNS, with gene expression enrichment in brain regions previously associated with substance u
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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KCNN1 variant and opioid use disorder risk Moderate
KCNN1 G allele is strongly associated with increased susceptibility to opioid use disorder, likely affecting potassium channel-mediated reward processing.
Share genetic information with prescribing physicians; request non-opioid alternatives for pain management.
Lifestyle
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opioid medications if alternatives available Moderate
Genetic variants in KCNN1 associated with opioid use disorder indicate heightened risk for dependence upon opioid exposure.
Request evidence-based non-opioid analgesics for acute or chronic pain management.