Expressive

rs11206301 - MRPL37

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery. - Atherosclerosis (2017) · Pott J, Burkhardt R, Beutner F, Horn K, Teren A, Kirsten H, Holdt LM, Schuler G, Teupser D, Loeffler M, Thiery J, Scholz M · PubMed 28282560

    Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. After investigating the reliability of plaque detection, we performed a genome-wide meta-association study in two independent cohorts (LIFE-Adult, n = 4037 and LIFE-Heart, n = 3152) for carotid plaque score (PS), defined as the sum of the plaque load of common carotid artery and carotid bulb. Further, we analyzed whether previously reported CAD and stroke loci were also associated with PS. We identified two loci with genome-wide significance for PS. One locus is the known CAD-locus at chromosome 9p21 (l

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean-style diet Moderate

    Mediterranean diet reduces atherosclerotic plaque progression and cardiovascular disease incidence

    Emphasize fish, olive oil, vegetables, whole grains, legumes; limit processed and refined foods

Discuss with your doctor

  • Discuss cardiovascular risk with healthcare provider Moderate

    SNP associated with increased carotid plaque burden, a marker of atherosclerotic cardiovascular disease risk requiring personalized assessment

    Discuss genetic finding, cardiovascular screening options, and personalized prevention strategies

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise reduces carotid plaque burden and cardiovascular disease incidence

    150 minutes per week moderate intensity or 75 minutes vigorous intensity aerobic exercise

Screening

  • Carotid atherosclerosis imaging screening Moderate

    SNP rs11206301 associated with increased carotid plaque burden; screening detects subclinical atherosclerosis for preventive intervention

    Carotid ultrasound at age 40-50; earlier if other cardiovascular risk factors present