rs11205000 - CCDST
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis. - The Journal of investigative dermatology (2022) · Chen Y, Chen W · PubMed 35577104
Atopic dermatitis (AD) is a common heterogeneous, chronic, itching, and inflammatory skin disease. Genetic studies have identified multiple AD susceptibility genes. However, the genetic architecture of AD has not been elucidated. In this study, we conducted a large-scale meta-analysis of AD (35,647 cases and 1,013,885 controls) to characterize the genetic basis of AD. The heritability of AD in different datasets varied from 0.6 to 7.1%. We identified 31 previously unreported genes by integrating multiomics data. Among the 31 genes, MCL1 was identified as a potential treatment target for AD by mediating gene‒drug interactions. Tissue enrichment analyses and phenome-wide association study provided strong support for the role of the hemic and immune systems in AD. Across 1,207 complex trait
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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daily emollient skin care regimen Moderate
Genetic predisposition increases atopic dermatitis risk via impaired skin barrier function
Daily moisturizer post-bathing; ceramide-based emollients preferred
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harsh soaps and fragrance-containing skin products Moderate
Genetic risk for atopic dermatitis is exacerbated by irritant and allergen exposure
Use fragrance-free mild cleansers; minimize hot water exposure
Screening
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dermatological assessment for atopic dermatitis Moderate
Strong genetic predisposition to atopic dermatitis (p<2e-17); early detection enables preventive intervention
Baseline assessment; annual monitoring if negative