rs11204894 - RORC
Magnitude 2.2 · 2 studies on file
Reported associations
-
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries - Unknown journal (n.d.) · Unknown authors · PubMed 37156999
ABSTRACT: Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most IBD genetic associations were derived from individuals of European ancestries (EUR). Here we report the largest IBD study of individuals of East Asian ancestries (EAS), including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among which 81 are novel. EAS enriched coding variants implicate many new IBD genes, including ADAP1 and GIT2. While IBD genetic effects are generally consistent across ancestries, genetics underlying CD appears more ancestry dependent than UC, driven by both allele frequency (NOD2) and effect (TN
-
A cross-disorder study to identify causal relationships, shared genetic variants, and genes across 21 digestive disorders - Unknown journal (n.d.) · Unknown authors · PubMed 37965154
ABSTRACT: Summary Digestive disorders are a significant contributor to the global burden of disease and seriously affect human quality of life. Research has already confirmed the presence of pleiotropic genetic loci among digestive disorders, and studies have explored shared genetic factors among pan-cancers, including various malignant digestive disorders. However, most cross-phenotype studies within the digestive tract system have been limited to a few traits, with no systematic coverage of common benign and malignant digestive disorders. Here, we analyzed data from the UK Biobank to investigate 21 digestive disorders, exploring the genetic correlations and causal relationships between diseases, as well as the common genetic factors and potential biological pathways driving these relatio
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic risk for inflammatory bowel disease High
RORC rs11204894 is associated with substantially elevated IBD and ulcerative colitis risk in large GWAS cohorts
Screening
-
gastrointestinal symptoms for inflammatory bowel disease High
rs11204894 risk allele carriers have substantially elevated genetic risk for IBD and ulcerative colitis; RORC is expressed in esophageal mucosa
Report persistent diarrhea, abdominal pain, blood in stool, or unexplained weight loss to provider