Expressive

rs11204533 - TRIM58

Magnitude 2.2 · 1 study on file

Reported associations

  • Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 37985223

    ABSTRACT: Abstract INTRODUCTION Although large‐scale genome‐wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. METHODS We conducted a cross‐ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts. RESULTS We found high heritability for two ancestry backgrounds. Further, we found a novel ancestry locus for memory decline on chromosome 4 (rs6848524) and three loci in the non‐Hispanic Black ancestry group for memory performance on chromosomes 2 (rs111471504), 7 (rs4142249), and 15 (rs74381744). In our gene‐level analysis, we found novel genes for memory d

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Cognitive health strategies with physician Moderate

    TRIM58 variant associated with memory decline; physician counseling enables personalized preventive approach.

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical exercise supports brain blood flow and cognitive function; may mitigate memory decline risk.

    150 minutes moderate aerobic + 2 days resistance training per week

Lifestyle

  • Cognitive engagement and mental stimulation Moderate

    Mental activity supports cognitive reserve and memory function; may offset memory decline risk.

    Daily cognitive engagement, 30+ minutes most days

  • Optimize sleep quality and duration Moderate

    Sleep is critical for memory consolidation and brain health; optimization may mitigate memory decline risk.

    Target 7-9 hours nightly with consistent sleep schedule

Screening

  • Baseline and periodic cognitive assessment Moderate

    rs11204533 in TRIM58 associated with increased memory decline risk; monitoring enables early detection.

    Baseline cognitive assessment, repeat every 1-2 years