Expressive

rs112040334 - KLF11

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways - Unknown journal (n.d.) · Unknown authors · PubMed 36050321

    ABSTRACT: The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for ce

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • serum potassium and magnesium levels Moderate

    Hypokalemia and hypomagnesemia prolong QT interval; genetic QT predisposition may amplify electrolyte sensitivity

    baseline measurement; annual monitoring or if symptoms develop; maintain K+ 4.0-5.0 mEq/L, Mg2+ >2.0 mg/dL

Discuss with your doctor

  • QT prolongation risk and medication review Moderate

    Many medications prolong QT; genetic predisposition increases individual risk of drug-induced arrhythmias

    Discuss QT risk with primary care; review medications for QT-prolonging potential with cardiologist

Screening

  • baseline ECG for QT interval assessment Moderate

    rs112040334 C allele associates with longer QT interval; baseline ECG quantifies individual risk

    obtain single baseline ECG; discuss results with cardiologist if QTc >460ms (women) or >450ms (men)