rs11203202 - UBASH3A
Magnitude 2.2 · 1 study on file
Reported associations
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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers - Unknown journal (n.d.) · Unknown authors · PubMed 25751624
ABSTRACT: Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions (www.T1DBase.org) revealing major pathways contributing to risk, with some loci shared across immune disorders. In order to make genetic comparisons across autoimmune disorders as informative as possible a dense genotyping array, the ImmunoChip, was developed, from which four novel T1D regions were identified (P < 5 × 10−8). A comparative analysis with 15 immune diseases (www.ImmunoBase.org) revealed that T1D is more similar genetically to other autoantibody-positive diseases, most significantly to juvenile idiopathic arthritis and least to ulcerative colitis, and provided support for three additional novel T1D loci. Using a Bayesian approach, we defined credible sets for the T1D SNPs. These T1D
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Symptoms of Type 1 diabetes High
Carriers of the risk allele at rs11203202 have elevated genetic risk for Type 1 diabetes onset at any age
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Type 1 diabetes baseline antibody and glucose screening High
G allele at rs11203202 is strongly associated with Type 1 diabetes risk (OR 1.160 in GWAS of 21526 individuals, p<1e-15)
Consult physician about baseline diabetes screening including HbA1c, fasting glucose, and diabetes autoantibodies