rs11203 - E2F6
Magnitude 2.2 · 1 study on file
Reported associations
-
Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 40645996
ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 252,438 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian ra
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic risk factors for atrial fibrillation and prevention strategy Moderate
This SNP explains heritable component of AFib risk through cardiac gene regulation
discuss with cardiologist for risk stratification and preventive measures tailored to personal and family history
Screening
-
baseline ECG and periodic cardiac rhythm assessment Moderate
rs11203 increases atrial fibrillation risk via altered E2F6 expression in cardiac tissues
obtain baseline ECG; repeat per cardiology recommendations (typically annually to every 3 years)