rs112022220 - LIMK1 - EIF4H
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107
Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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heavy lifting and excessive abdominal straining Moderate
Heavy lifting and straining increase intra-abdominal pressure, a primary mechanical risk factor for hernia formation.
Limit repetitive heavy lifting to less than 20-25 lbs; use proper technique with knees bent
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maintaining healthy body weight Moderate
Obesity increases intra-abdominal pressure and connective tissue stress, elevating hernia risk in genetically predisposed individuals.
Maintain BMI 18.5-24.9; pursue gradual weight loss if currently overweight
Screening
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for inguinal hernia development or symptoms Moderate
Genetic variant is associated with 15 percent increased inguinal hernia risk; early detection enables timely intervention.
Regular self-examination for groin bulges or lumps, particularly when standing or straining