rs112014566 - RNY4P18 - MIR7702

Magnitude 2.2 · 1 study on file

Reported associations

• Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 35330412

  ABSTRACT: Age at depressive onset (AAO) corresponds to unique symptomatology and clinical outcomes. Integration of genome-wide association study (GWAS) results with additional "omic" measures to evaluate AAO has not been reported and may reveal novel markers of susceptibility and/or resistance to major depressive disorder (MDD). To address this gap, we integrated genomics with metabolomics using data-driven network analysis to characterize and differentiate MDD based on AAO. This study first performed two GWAS for AAO as a continuous trait in (a) 486 adults from the Pharmacogenomic Research Network-Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS), and (b) 295 adults from the Combining Medications to Enhance Depression Outcomes (CO-MED) study. Variants from top signals were i

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