rs112012087
Magnitude 2.2 · 1 study on file
Reported associations
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A genetic map of human metabolism across the allele frequency spectrum - Unknown journal (n.d.) · Unknown authors · PubMed 41044249
ABSTRACT: Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Limit refined carbohydrates and added sugars Moderate
Refined carbohydrates elevate triglycerides; this SNP confers genetic predisposition to elevated triglycerides
Reduce refined grains, sugary beverages, and added sugars; increase whole grains and fiber
Exercise
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Regular aerobic exercise Moderate
Aerobic exercise reduces triglycerides; this SNP is associated with elevated triglycerides
150 minutes per week of moderate-intensity aerobic activity
Screening
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Triglyceride and VLDL cholesterol levels Moderate
rs112012087 is associated with increased triglyceride levels and large VLDL cholesterol concentrations in large-scale population studies
Obtain baseline lipid panel including triglycerides and VLDL; repeat annually