rs111970692 - CTSH

Magnitude 2.2 · 1 study on file

Reported associations

• Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 39556808

  ABSTRACT: Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large meta-genome-wide association studies (GWAS) of C-peptide and AAD in T1D and to identify the HLA allele/haplotypes associated with C-peptide and AAD. A total of 7,252 and 7,923 European individuals with T1D were included in C-peptide and AAD GWAS, respectively. HLA-DQB106:02, which is strongly protective against T1D, was associated with higher C-peptide. HLA-DQB103:02, HLA-DRB103:01, and HLA-A24:02, which increase T1D risk, were independently associated with younger AAD. HLA-DR3-DR4 haplotype combination, the strongest T1D susceptibility factor, was associated with younger AAD. Outside t

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