Expressive

rs111970601 - RIMBP2

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM polygenic risk score study. - Environmental research (2025) · Kelchtermans J, March ME, Mentch F, Qu H, Liu Y, Nguyen K, Hakonarson H · PubMed 39725137

    Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap. To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma. We complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM . This PRS was validated using internal data and data from the All of Us cohort. We included 6023 patients in the GWAS, restricted to the African ancestry cohort due to the association between AAP exposure and race. Three loci reached genome-wide signifi

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic CO sensitivity and personalized air quality management strategy Moderate

    rs111970601 represents specific genetic vulnerability to carbon monoxide that may warrant targeted environmental precautions and medication optimization

    Discuss with pulmonologist or allergist whether additional preventive measures are warranted given genotype-specific CO sensitivity

Lifestyle

  • CO pollution exposure on high air quality index days Moderate

    rs111970601 is associated with 6.58-fold increased odds of asthma exacerbation following carbon monoxide exposure in ambient air pollution

    Check local air quality index daily; use air quality apps; limit outdoor exertion on high pollution days

  • home air quality control systems for CO reduction Moderate

    strong genetic association with CO-induced asthma exacerbations suggests environmental control of both indoor and outdoor CO exposure may reduce risk

    Consider CO monitor for home; assess heating appliances for leaks; use activated carbon air filtration if high outdoor pollution exposure