rs11196569 - NHLRC2 - ADRB1
Magnitude 2.2 · 1 study on file
Reported associations
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Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 36329257
ABSTRACT: To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and HbA1c) was performed and identified 115 significant loci with four novel genetic variants (HACL1, RAD21, ASH1L and GAK). Transcriptomics data also strengthen the relevancy of the findings to metabolic disorders, thus contributing to better understanding of pathogenesis. In addition, genetic risk sc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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blood pressure management and cardiovascular risk Moderate
ADRB1 rs11196569 association with elevated diastolic BP warrants professional assessment of individual risk and appropriate management strategy
schedule appointment to discuss findings and management options
Screening
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blood pressure measurement Moderate
ADRB1 rs11196569 carriers have increased diastolic blood pressure; monitoring establishes baseline and detects changes requiring intervention
baseline measurement at next visit; annual follow-up measurements