rs11196288 - TCF7L2 - RNU7-165P

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2 - Unknown journal (n.d.) · Unknown authors · PubMed 26732560

  ABSTRACT: Background and Purpose Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a two-stage meta-analysis of genome-wide association studies (GWAS), focusing on stroke cases with an age of onset < 60 years old. Methods The Discovery stage of our GWAS included 4,505 cases and 21,968 controls of European, South-Asian and African ancestry, drawn from 6 studies. In Stage 2, we selected the lead genetic variants at loci with association P<5×10−6 and performed in silico association analyses in an independent sample of up to 1,003 cases and 7,745 controls. Results One

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