Expressive

rs11196182 - TCF7L2

Magnitude 2.2 · 1 study on file

Reported associations

  • The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 37148359

    ABSTRACT: Aims/hypothesis The Latino population has been systematically underrepresented in large-scale genetic analyses, and previous studies have relied on the imputation of ungenotyped variants based on the 1000 Genomes (1000G) imputation panel, which results in suboptimal capture of low-frequency or Latino-enriched variants. The National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) released the largest multi-ancestry genotype reference panel representing a unique opportunity to analyse rare genetic variations in the Latino population. We hypothesise that a more comprehensive analysis of low/rare variation using the TOPMed panel would improve our knowledge of the genetics of type 2 diabetes in the Latino population. Methods We evaluated the TOPMed

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Reduce refined carbohydrates and added sugars Moderate

    Refined carbs and high-glycemic foods impair glucose control in diabetes-susceptible individuals.

    Choose whole grains; limit added sugars; aim for 25-30g daily dietary fiber.

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and reduces diabetes incidence in genetically susceptible individuals.

    150 minutes weekly moderate-intensity aerobic exercise plus 2 days resistance training.

Lifestyle

  • Weight management to healthy BMI range Moderate

    Excess weight increases diabetes penetrance in TCF7L2 risk carriers by exacerbating insulin resistance.

    Target BMI 18.5-24.9 kg/m2; if overweight, aim for 5-10% weight loss.

Screening

  • HbA1c and fasting glucose screening annually Moderate

    TCF7L2 variants impair beta-cell function and glucose homeostasis, increasing type 2 diabetes risk.

    Annual HbA1c and fasting glucose; glucose tolerance test if prediabetic.